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KMID : 0614619940260040675
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Korean Journal of Gastroenterology
1994 Volume.26 No. 4 p.675 ~ p.682
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Gallbladder Contraction and Plasma Cholecytokinin in Response to Fat in the Duodenum
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이상인/William Y Chey
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Abstract
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The aim of this study is to determine if fat in the duodenum affects gallbladder contraction and plasma cholecystokinin. We evaluated the effect of intraduodenal(i.d.) lipomul on plasma concentration of cholecystokinin-like
immunoreactivity(CCK-LI)
and
gallbladder(GB) contraction were studied. GB contraction was calculated by measuring GB volume by serial ultrasonograms and expressed as % of the basal volume. Whereas iv saline failed to influence either plasma CCK-LI or GB volume, lipomul in 3
different doses(0.25, 0.5, 1.0ml/kg) produced significant increases(P<0.05) in plasma CCK-LI and significant decreases(P<0.05) in GB volume during a 90 min period of observation. However, the responses of CCK-LI and GB volume were not dose
related.
Atropine sulfate given iv, 15ug/kg/hr, inhibited lipomul induced GB contraction during the first 15 min which was followed by partial contraction(not significant). No significant effect of atropine on plasma CCK-LI was apparent also. Thus we
conclude
that lipomul produced significant increases in contraction of GB and plasma CCK-LI. The peak concentration of CCK-LI coincided with the maximum GB contraction. Atropine did not significantly influence lipomul-stimulated GB contraction and did not
influence plasma CCK-LI. Thus no significant cholinergic effect was apparent.(Korean J Gastroenterol 1994 ; 26 : 675-682)
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